Article
Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling.
BMC developmental biology - 29 Sept 2011
Doggett Karen, Grusche Felix A, Richardson Helena E, Brumby Anthony M
Abstract excerpt
BACKGROUND: Epithelial neoplasias are associated with alterations in cell polarity and excessive cell proliferation, yet how these neoplastic properties are related to one another is still poorly understood. The study of Drosophila genes that function as neoplastic tumor suppressors by regulating both of these properties has significant potential to clarify this relationship. RESULTS: Here we show in Drosophila...
Topics
- Animals
- Cell Polarity
- Cell Proliferation
- Drosophila Proteins
- Drosophila melanogaster
- Epithelial Cells
- Eye
- Intracellular Signaling Peptides and Proteins
- Membrane Proteins
- Mutation
- Nuclear Proteins
- Oncogene Protein p21(ras)
- Protein Kinase C