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Article

scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila.

The EMBO journal - 3 Nov 2003

Brumby Anthony M, Richardson Helena E

Abstract excerpt

Cancer is a multistep process involving cooperation between oncogenic or tumor suppressor mutations and interactions between the tumor and surrounding normal tissue. Here we present the first description of cooperative tumorigenesis in Drosophila, by using a system that mimics the development of tumors in mammals. We have used the MARCM system to generate mutant clones of the apical-basal cell polarity tumor...

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Identifiers

PMID: 14592975
DOI: 10.1093/emboj/cdg548
PMCID: PMC275405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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