Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors.

Science (New York, N.Y.) - 7 Jul 2000

Bilder D, Li M, Perrimon N

Abstract excerpt

Loss of cell polarity and tissue architecture are characteristics of malignant cancers derived from epithelial tissues. We provide evidence from Drosophila that a group of membrane-associated proteins act in concert to regulate both epithelial structure and cell proliferation. Scribble (Scrib) is a cell junction-localized protein required for polarization of embryonic and, as demonstrated here, imaginal disc and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Polarity
Share to Embryo, Nonmammalian
Share to Epidermis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Insect

Share to Genes, Tumor Suppressor

Share to Insect Proteins

Share to Intercellular Junctions

Share to Morphogenesis

Source

Identifiers

PMID: 10884224
DOI: 10.1126/science.289.5476.113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors.PMID 10884224Read ↗

Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer.Semantic proximity Read ↗

Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor Scribble.Semantic proximity Read ↗

Regulation of cellular and PCP signalling by the Scribble polarity module.Semantic proximity Read ↗

Basolateral junctions utilize warts signaling to control epithelial-mesenchymal transition and proliferation crucial for migration and invasion of Drosophila ovarian epithelial cells.Semantic proximity Read ↗

Polarity protein complex Scribble/Lgl/Dlg and epithelial cell barriers.Semantic proximity Read ↗

Scribble protein domain mapping reveals a multistep localization mechanism and domains necessary for establishing cortical polarity.Semantic proximity Read ↗

Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling.Semantic proximity Read ↗

Loss of Cell Adhesion Increases Tumorigenic Potential of Polarity Deficient Scribble Mutant Cells.Semantic proximity Read ↗

scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila.Semantic proximity Read ↗

Regulation of imaginal disc growth by tumor-suppressor genes in Drosophila.Semantic proximity Read ↗

The transcriptional response to tumorigenic polarity loss in Drosophila.Semantic proximity Read ↗

Integrated activity of PDZ protein complexes regulates epithelial polarity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.