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Article

Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms.

Current biology : CB - 13 Apr 2010

Grzeschik Nicola A, Parsons Linda M, Allott Melinda L, Harvey Kieran F, Richardson Helena E

Abstract excerpt

BACKGROUND: The Drosophila neoplastic tumor suppressor Lethal (2) giant larvae (Lgl) controls apicobasal cell polarity and proliferation. We have previously shown that lgl(-) clones in the developing eye exhibit ectopic proliferation and suppress apoptosis without affecting apicobasal cell polarity. Ectopic expression of the apical polarity regulators atypical protein kinase C (aPKC) and Crumbs also leads to...

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Identifiers

PMID: 20362447
DOI: 10.1016/j.cub.2010.01.055

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms.PMID 20362447Read ↗

Lgl/aPKC and Crb regulate the Salvador/Warts/Hippo pathway.Semantic proximity Read ↗

Lgl, the SWH pathway and tumorigenesis: It's a matter of context & competition!Semantic proximity Read ↗

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The Hippo pathway regulates apical-domain size independently of its growth-control function.Semantic proximity Read ↗

The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila.Semantic proximity Read ↗

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Kibra is a regulator of the Salvador/Warts/Hippo signaling network.Semantic proximity Read ↗

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