Article
The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy.
BMC biology - 7 Apr 2010
Froldi Francesca, Ziosi Marcello, Garoia Flavio, Pession Andrea, Grzeschik Nicola A, Bellosta Paola, Strand Dennis, Richardson Helena E, Pession Annalisa, Grifoni Daniela
Abstract excerpt
BACKGROUND: Neoplastic overgrowth depends on the cooperation of several mutations ultimately leading to major rearrangements in cellular behaviour. Precancerous cells are often removed by cell death from normal tissues in the early steps of the tumourigenic process, but the molecules responsible for such a fundamental safeguard process remain in part elusive. With the aim to investigate the molecular crosstalk...
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