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Article

Regulation of imaginal disc growth by tumor-suppressor genes in Drosophila.

Annual review of genetics - 1 Jan 2006

Hariharan Iswar K, Bilder David

Abstract excerpt

Inactivating mutations in the Drosophila tumor-suppressor genes result in tissue overgrowth. This can occur because the mutant tissue either grows faster than wild-type tissue and/or continues to grow beyond a time when wild-type tissue stops growing. There are three general classes of tumor-suppressor genes that regulate the growth of imaginal disc epithelia. Mutations in the hyperplastic tumor-suppressor genes...

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PMID: 16872256
DOI: 10.1146/annurev.genet.39.073003.100738

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