Back to search

Article

<i>scribble</i> abrogation induces tumor growth through JNK-Wnt pathways depending on cellular-microenvironment in <i>Drosophila</i> wing imaginal tissue

2019-08-01

Abstract excerpt

scribble ( scrib ) is a cell-polarity determinant in Drosophila and human. Cell polarity plays a crucial role in the maintenance of tissue homeostasis and its disruption leads to neoplastic cancer progression. However, the underlying mechanisms by which loss of cell-polarity regulators drives cancer progression are poorly known. In this study, we have explored the tumor progression mechanisms upon scrib knockdo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d9191520-7e8e-5c36-ab9b-f9ca0f87ddb6
DOI
10.1101/721407
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
<i>scribble</i> abrogation induces tumor growth through JNK-Wnt pathways depending on cellular-microenvironment in <i>Drosophila</i> wing imaginal tissueDOI 10.1101/721407
<i>Scribble</i> knockdown induced metastasis tracking, identification of its associated novel molecular candidates through Proteome and <i>in silico</i> studiesSemantic proximity
JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila.Semantic proximity
scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila.Semantic proximity
Aneuploidy-induced delaminating cells drive tumorigenesis in <i>Drosophila</i> epitheliaSemantic proximity
Loss of Cell Adhesion Increases Tumorigenic Potential of Polarity Deficient Scribble Mutant Cells.Semantic proximity
Scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs.Semantic proximity
Tumor suppression by cell competition through regulation of the Hippo pathway.Semantic proximity
Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling.Semantic proximity
<i>Drp1-JNK</i> knockdown mitigates Scribble loss induced cell proliferation, metastasis and lethality phenotypes in <i>Drosophila</i>Semantic proximity
<i>Drosophila scribble</i> mutant tumors undergo a transition from a growth arrest state to a proliferative state over timeSemantic proximity
Mechanisms underlying the cooperation between loss of epithelial polarity and Notch signaling during neoplastic growth in Drosophila.Semantic proximity
Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor Scribble.Semantic proximity
Select a neighboring publication to make it the new centre.