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Article

Lgl/aPKC and Crb regulate the Salvador/Warts/Hippo pathway.

Fly - 1 Jan 2000

Parsons Linda M, Grzeschik Nicola A, Allott Melinda L, Richardson Helena E

Abstract excerpt

A key goal of developmental biology is to understand the mechanisms that coordinate organ growth. It has long been recognized that the genes that control apico-basal cell polarity also regulate tissue growth. How loss of cell polarity contributes to tissue overgrowth has been the subject of much speculation. Do loss-of-function mutations in cell polarity regulators result in secondary effects that globally...

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Identifiers

PMID: 20798605
DOI: 10.4161/fly.4.4.13116
PMCID: PMC3174480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lgl/aPKC and Crb regulate the Salvador/Warts/Hippo pathway.PMID 20798605Read ↗

Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms.Semantic proximity Read ↗

Lgl, the SWH pathway and tumorigenesis: It's a matter of context & competition!Semantic proximity Read ↗

Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded.Semantic proximity Read ↗

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded.Semantic proximity Read ↗

Crumbs promotes expanded recognition and degradation by the SCF(Slimb/β-TrCP) ubiquitin ligase.Semantic proximity Read ↗

Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling.Semantic proximity Read ↗

Kibra is a regulator of the Salvador/Warts/Hippo signaling network.Semantic proximity Read ↗

Scribble acts in the Drosophila fat-hippo pathway to regulate warts activity.Semantic proximity Read ↗

The role of the Hippo pathway in human disease and tumorigenesisSemantic proximity Read ↗

Scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs.Semantic proximity Read ↗

The Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and Warts.Semantic proximity Read ↗

The Hippo pathway regulates apical-domain size independently of its growth-control function.Semantic proximity Read ↗

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