Lgl/aPKC and Crb regulate the Salvador/Warts/Hippo pathway.

doi:10.4161/fly.4.4.13116

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Article

Lgl/aPKC and Crb regulate the Salvador/Warts/Hippo pathway.

Fly - 1 Jan 2000

Parsons Linda M, Grzeschik Nicola A, Allott Melinda L, Richardson Helena E

Abstract excerpt

A key goal of developmental biology is to understand the mechanisms that coordinate organ growth. It has long been recognized that the genes that control apico-basal cell polarity also regulate tissue growth. How loss of cell polarity contributes to tissue overgrowth has been the subject of much speculation. Do loss-of-function mutations in cell polarity regulators result in secondary effects that globally...

Topics

Animals
Carrier Proteins
Cell Cycle Proteins
Cell Polarity
Drosophila Proteins
Drosophila melanogaster
Gene Expression Regulation
Intracellular Signaling Peptides and Proteins
Membrane Proteins
Mutation
Protein Kinase C
Protein Kinases
Protein Serine-Threonine Kinases
Signal Transduction
Tumor Suppressor Proteins

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Identifiers

PMID: 20798605
DOI: 10.4161/fly.4.4.13116
PMCID: PMC3174480

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