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Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Jun 2003

Humbert Patrick, Russell Sarah, Richardson Helena

Abstract excerpt

Dlg (Discs large), Scrib (Scribble) and Lgl (Lethal giant larvae) are evolutionarily conserved components of a common genetic pathway that link the seemingly disparate functions of cell polarity and cell proliferation in epithelial cells. dlg, scrib and lgl have been identified as tumour suppressor genes in Drosophila, mutations of which cause similar phenotypes, involving disruption of cell polarity and...

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Identifiers

PMID: 12766944
DOI: 10.1002/bies.10286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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