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Article

Hand2 inhibits kidney specification while promoting vein formation within the posterior mesoderm.

eLife - 2 Nov 2016

Perens Elliot A, Garavito-Aguilar Zayra V, Guio-Vega Gina P, Peña Karen T, Schindler Yocheved L, Yelon Deborah

Abstract excerpt

Proper organogenesis depends upon defining the precise dimensions of organ progenitor territories. Kidney progenitors originate within the intermediate mesoderm (IM), but the pathways that set the boundaries of the IM are poorly understood. Here, we show that the bHLH transcription factor Hand2 limits the size of the embryonic kidney by restricting IM dimensions. The IM is expanded in zebrafish hand2 mutants and...

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Identifiers

PMID: 27805568
DOI: 10.7554/eLife.19941
PMCID: PMC5132343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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