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Article

Asymmetric Hapln1a drives regionalized cardiac ECM expansion and promotes heart morphogenesis in zebrafish development.

Cardiovascular research - 7 Jan 2022

Derrick Christopher J, Sánchez-Posada Juliana, Hussein Farah, Tessadori Federico, Pollitt Eric J G, Savage Aaron M, Wilkinson Robert N, Chico Timothy J, van Eeden Fredericus J, Bakkers Jeroen, Noël Emily S

Abstract excerpt

AIMS: Vertebrate heart development requires the complex morphogenesis of a linear tube to form the mature organ, a process essential for correct cardiac form and function, requiring coordination of embryonic laterality, cardiac growth, and regionalized cellular changes. While previous studies have demonstrated broad requirements for extracellular matrix (ECM) components in cardiac morphogenesis, we hypothesized...

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PMID: 33616638
DOI: 10.1093/cvr/cvab004
PMCID: PMC8752364

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