Article
Colorectal cancers in patients with the (9A/6A) polymorphism of TGFBR1 exhibit lesser inter-(simple sequence repeat) PCR genomic instability and present clinically at greater age.
Mutation research - 14 Oct 2008
Dutt Smitha S, Chen Neng, Darbary Huferesh K, Swede Helen, Petrelli Nicholas J, Stoler Daniel L, Anderson Garth R
Abstract excerpt
TGFbeta is involved in the response to DNA damage and signaling the cell cycle checkpoint response, in large part achieved by modulating the activity of the ATM kinase. We have investigated if the presence of a common polymorphism in the TGFbeta receptor TGFBR1 might impact genomic instability in human colorectal cancer. In order to obtain statistically significant numbers of patients with the lesser...
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