Article
No association between germline allele-specific expression of TGFBR1 and colorectal cancer risk in Caucasian and Ashkenazi populations.
British journal of cancer - 15 Feb 2011
Seguí N, Stevens K N, Guinó E, Rozek L S, Moreno V R, Capellá G, Gruber S B, Valle L
Abstract excerpt
BACKGROUND: Germline allele-specific expression (ASE) of the TGFBR1 gene has been reported as a strong risk factor for colorectal cancer (CRC) with an odds ratio close to 9. Considering the potential implications of the finding, we undertook the task of validating the initial results in this study. METHODS: Allele-specific expression was measured using the highly quantitative and robust technique of...
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