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Article

The effect of class II transactivator mutations on bleomycin-induced lung inflammation and fibrosis.

American journal of respiratory cell and molecular biology - 1 Jun 2011

Xu Yong, Luchsinger Larry, Lucey Edgar C, Smith Barbara D

Abstract excerpt

IFN-γ expression increases during the inflammatory response after bleomycin injury in mice. IFN-γ deficiency attenuates lung inflammation and fibrosis. Because IFN-γ stimulates class II transactivator (CIITA) expression, which activates major histocompatibility class (MHC) II and represses collagen expression, it was hypothesized that CIITA mediates IFN-γ action after bleomycin injury. To test this hypothesis,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20705943
DOI: 10.1165/rcmb.2009-0416OC
PMCID: PMC3135849

Genes

CIITA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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