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Article

Protection from fluorescein isothiocyanate-induced fibrosis in IL-13-deficient, but not IL-4-deficient, mice results from impaired collagen synthesis by fibroblasts.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2004

Kolodsick Jill E, Toews Galen B, Jakubzick Claudia, Hogaboam Cory, Moore Thomas A, McKenzie Andrew, Wilke Carol A, Chrisman Cara J, Moore Bethany B

Abstract excerpt

Intratracheal injection of FITC results in acute lung injury and progresses to fibrosis by day 21 postchallenge. In response to FITC, BALB/c mice produce IL-4 and IL-13 in the lung. To investigate whether IL-4 and/or IL-13 were important profibrotic mediators in this model, we examined the fibrot...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15034018
DOI: 10.4049/jimmunol.172.7.4068

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15034018-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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