Article
An essential role for CCAAT/enhancer binding protein beta in bleomycin-induced pulmonary fibrosis.
The Journal of pathology - 1 Mar 2007
Hu B, Ullenbruch M R, Jin H, Gharaee-Kermani M, Phan S H
Abstract excerpt
Pulmonary fibrosis is characterized by inflammation, genesis of myofibroblasts, and abnormal tissue repair. Despite extensive research, its pathogenesis remains incompletely understood. Previously, the transcription factor CCAAT/enhancer binding protein beta (C/EBPbeta) was found to be a key regulator of myofibroblast differentiation in vitro, and to be involved in the acute phase and inflammatory responses. In...
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