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Article

IFN-γ Blocks Development of an Asthma Phenotype in Rhinovirus-Infected Baby Mice by Inhibiting Type 2 Innate Lymphoid Cells.

American journal of respiratory cell and molecular biology - 1 Feb 2017

Han Mingyuan, Hong Jun Young, Jaipalli Suraj, Rajput Charu, Lei Jing, Hinde Joanna L, Chen Qiang, Hershenson Natalie M, Bentley J Kelley, Hershenson Marc B

Abstract excerpt

Early-life wheezing-associated infections with rhinovirus (RV) have been associated with asthma development in children. We have shown that RV infection of 6-day-old mice induces mucous metaplasia and airways hyperresponsiveness, which is dependent on IL-13, IL-25, and type 2 innate lymphoid cells (ILC2s). Infection of immature mice fails to induce lung IFN-γ expression, in contrast to mature 8-week-old mice with...

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Identifiers

PMID: 27679954
DOI: 10.1165/rcmb.2016-0056OC
PMCID: PMC5359646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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