Article
Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium.
Proceedings of the National Academy of Sciences of the United States of America - 6 Dec 2005
Broide David H, Lawrence Toby, Doherty Taylor, Cho Jae Youn, Miller Marina, McElwain Kirsti, McElwain Shauna, Karin Michael
Abstract excerpt
In response to inflammation or injury, airway epithelial cells express inducible genes that may contribute to allergen-induced airway remodeling. To determine the contribution of epithelial cell NF-kappaB activation to the remodeling response, we generated CC10-Cre(tg)/Ikkbeta(delta/delta) mice in which NF-kappaB signaling through IkappaB kinase beta (IKKbeta) is selectively ablated in the airway epithelium by...
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