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Article

Role of CCR5 in IFN-gamma-induced and cigarette smoke-induced emphysema.

The Journal of clinical investigation - 1 Dec 2005

Ma Bing, Kang Min-Jong, Lee Chun Geun, Chapoval Svetlana, Liu Wei, Chen Qingsheng, Coyle Anthony J, Lora José M, Picarella Dominic, Homer Robert J, Elias Jack A

Abstract excerpt

Th1 inflammation and remodeling characterized by tissue destruction frequently coexist in human diseases. To further understand the mechanisms of these responses, we defined the role(s) of CCR5 in the pathogenesis of IFN-gamma-induced inflammation and remodeling in a murine emphysema model. IFN-gamma was a potent stimulator of the CCR5 ligands macrophage inflammatory protein-1alpha/CCL-3 (MIP-1alpha/CCL-3),...

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Source

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Identifiers

PMID: 16284650
DOI: 10.1172/JCI24858
PMCID: PMC1280966

Genes

CCR5
MIP
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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