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Article

A role for matrix metalloproteinase 9 in IFNγ-mediated injury in developing lungs: relevance to bronchopulmonary dysplasia.

American journal of respiratory cell and molecular biology - 1 May 2011

Harijith Anantha, Choo-Wing Rayman, Cataltepe Sule, Yasumatsu Ryuji, Aghai Zubair H, Janér Joakim, Andersson Sture, Homer Robert J, Bhandari Vineet

Abstract excerpt

We noted a marked increase in IFNγ mRNA in newborn (NB) murine lungs after exposure to hyperoxia. We sought to evaluate the role of IFNγ in lung injury in newborns. Using a unique triple-transgenic (TTG), IFNγ-overexpressing, lung-targeted, externally regulatable NB murine model, we describe a lung phenotype of impaired alveolarization, resembling human bronchopulmonary dysplasia (BPD). IFNγ-mediated abnormal...

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Source

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Identifiers

PMID: 21216975
DOI: 10.1165/rcmb.2010-0058OC
PMCID: PMC3095982

Genes

MMP9
CXCL10
CXCL11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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