Article
Genetic ablation of interferon-gamma up-regulates interleukin-1beta expression and enables the elicitation of collagen-induced arthritis in a nonsusceptible mouse strain.
Arthritis and rheumatism - 1 Oct 2001
Guedez Y B, Whittington K B, Clayton J L, Joosten L A, van de Loo F A, van den Berg W B, Rosloniec E F
Abstract excerpt
OBJECTIVE: To determine whether the lack of interferon-gamma (IFNgamma) alters resistance to collagen-induced arthritis (CIA) in a nonsusceptible mouse strain, and if so, to identify changes in the antibody, cellular type II collagen (CII)-specific immune responses, and cytokine gene expression that might account for the altered susceptibility. METHODS: CIA-resistant C57BL/6 and C57BL/6 IFNgamma-/- mice were...
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