Article
Relationships between early inflammatory response to bleomycin and sensitivity to lung fibrosis: a role for dipeptidyl-peptidase I and tissue inhibitor of metalloproteinase-3?
American journal of respiratory and critical care medicine - 1 Dec 2007
Pottier Nicolas, Chupin Cécile, Defamie Virginie, Cardinaud Bruno, Sutherland Rachel, Rios Géraldine, Gauthier Francis, Wolters Paul J, Berthiaume Yves, Barbry Pascal, Mari Bernard
Abstract excerpt
RATIONALE: Different sensitivities to profibrotic compounds such as bleomycin are observed among mouse strains. OBJECTIVES: To identify genetic factors contributing to the outcome of lung injury. METHODS: Physiological comparison of C57BL/6 (sensitive) and BALB/c (resistant) mice challenged by intratracheal bleomycin instillation revealed several early differences: global gene expression profiles were thus...
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