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Article

Deacetylation of p53 induces autophagy by suppressing Bmf expression

29 Apr 2013

Abstract excerpt

Interferon γ (IFN-γ)-induced cell death is mediated by the BH3-only domain protein, Bik, in a p53-independent manner. However, the effect of IFN-γ on p53 and how this affects autophagy have not been reported. The present study demonstrates that IFN-γ down-regulated expression of the BH3 domain-only protein, Bmf, in human and mouse airway epithelial cells in a p53-dependent manner. p53 also suppressed Bmf...

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PMID: 23629966
DOI: 10.1083/jcb.201205064

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