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Article

Mkp1 is a c-Jun target gene that antagonizes JNK-dependent apoptosis in sympathetic neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 11 Aug 2010

Kristiansen Mark, Hughes Rosie, Patel Pritika, Jacques Thomas S, Clark Andrew R, Ham Jonathan

Abstract excerpt

Developing sympathetic neurons depend on NGF for survival. When sympathetic neurons are deprived of NGF in vitro, a well documented series of events, including c-Jun N-terminal kinase (JNK) pathway activation, release of cytochrome c from the mitochondria, and caspase activation, culminates in the death of the neuron by apoptosis within 24-48 h. This process requires de novo gene expression, suggesting that...

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Source

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Identifiers

PMID: 20702711
DOI: 10.1523/JNEUROSCI.2824-10.2010
PMCID: PMC3044878

Genes

NGF
ATF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Mkp1 is a c-Jun target gene that antagonizes JNK-dependent apoptosis in sympathetic neurons.PMID 20702711Read ↗

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Pin1 promotes cell death in NGF-dependent neurons through a mechanism requiring c-Jun activity.Semantic proximity Read ↗

JNK3 contributes to c-Jun activation and apoptosis but not oxidative stress in nerve growth factor-deprived sympathetic neurons.Semantic proximity Read ↗

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A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death.Semantic proximity Read ↗

Distinct roles of c-Jun N-terminal kinase isoforms in neurite initiation and elongation during axonal regeneration.Semantic proximity Read ↗

FOXO transcription factors directly activate <i>bim</i> gene expression and promote apoptosis in sympathetic neuronsSemantic proximity Read ↗

NRAGE, a p75NTR adaptor protein, is required for developmental apoptosis in vivo.Semantic proximity Read ↗

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