Article
c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation.
The Journal of cell biology - 5 Aug 2002
Palmada M, Kanwal S, Rutkoski N J, Gustafson-Brown C, Johnson R S, Wisdom R, Carter B D, Gufstafson-Brown C
Abstract excerpt
Sympathetic neurons depend on NGF binding to TrkA for their survival during vertebrate development. NGF deprivation initiates a transcription-dependent apoptotic response, which is suggested to require activation of the transcription factor c-Jun. Similarly, apoptosis can also be induced by selective activation of the p75 neurotrophin receptor. The transcriptional dependency of p75-mediated cell death has not...
Topics
- Animals
- Apoptosis
- Base Sequence
- Brain-Derived Neurotrophic Factor
- Cells, Cultured
- Cycloheximide
- Gene Expression Regulation, Developmental
- Genetic Vectors
- Green Fluorescent Proteins
- Immunohistochemistry
- Indicators and Reagents
- Integrases
- Luminescent Proteins