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Article

Distinct roles of c-Jun N-terminal kinase isoforms in neurite initiation and elongation during axonal regeneration.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 Jun 2010

Barnat Monia, Enslen Hervé, Propst Friedrich, Davis Roger J, Soares Sylvia, Nothias Fatiha

Abstract excerpt

c-Jun N-terminal kinases (JNKs) (comprising JNK1-3 isoforms) are members of the MAPK (mitogen-activated protein kinase) family, activated in response to various stimuli including growth factors and inflammatory cytokines. Their activation is facilitated by scaffold proteins, notably JNK-interacting protein-1 (JIP1). Originally considered to be mediators of neuronal degeneration in response to stress and injury,...

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Identifiers

PMID: 20534829
DOI: 10.1523/JNEUROSCI.0372-10.2010
PMCID: PMC6632683

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