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Article

FOXO transcription factors directly activate <i>bim</i> gene expression and promote apoptosis in sympathetic neurons

11 Aug 2003

Abstract excerpt

Developing sympathetic neurons die by apoptosis when deprived of NGF. BIM, a BH3-only member of the BCL-2 family, is induced after NGF withdrawal in these cells and contributes to NGF withdrawal-induced death. Here, we have investigated the involvement of the Forkhead box, class O (FOXO) subfamily of Forkhead transcription factors in the regulation of BIM expression by NGF. We find that overexpression of FOXO...

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PMID: 12913110
DOI: 10.1083/jcb.200303026

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