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Article

Pin1 promotes cell death in NGF-dependent neurons through a mechanism requiring c-Jun activity.

Journal of neurochemistry - 1 Jul 2008

Barone Maria Cecilia, Desouza Lynette A, Freeman Robert S

Abstract excerpt

Developing neurons deprived of trophic support undergo apoptosis mediated by activation of c-Jun N-terminal kinases (JNK) and c-Jun, induction of the Bcl-2 homology 3-only protein Bim(EL), Bax-dependent loss of mitochondrial cytochrome c, and caspase activation. However, the mechanisms that regulate each of these events are only partially understood. Here we show that the prolyl isomerase Pin1 functions as a...

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Source

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Identifiers

PMID: 18419764
DOI: 10.1111/j.1471-4159.2008.05427.x
PMCID: PMC2574869

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pin1 promotes cell death in NGF-dependent neurons through a mechanism requiring c-Jun activity.PMID 18419764Read ↗

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