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Article

The proapoptotic dp5 gene is a direct target of the MLK-JNK-c-Jun pathway in sympathetic neurons.

Nucleic acids research - 1 May 2009

Towers Emily, Gilley Jonathan, Randall Rebecca, Hughes Rosie, Kristiansen Mark, Ham Jonathan

Abstract excerpt

The death of sympathetic neurons after nerve growth factor (NGF) withdrawal requires de novo gene expression. Dp5 was one of the first NGF withdrawal-induced genes to be identified and it encodes a proapoptotic BH3-only member of the Bcl-2 family. To study how dp5 transcription is regulated by NGF withdrawal we cloned the regulatory regions of the rat dp5 gene and constructed a series of dp5-luciferase reporter...

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Source

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Identifiers

PMID: 19304750
DOI: 10.1093/nar/gkp175
PMCID: PMC2685101

Genes

NGF
ATF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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