A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death.

doi:10.1016/0896-6273(95)90331-3

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Article

A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death.

Neuron - 1 May 1995

Ham J, Babij C, Whitfield J, Pfarr C M, Lallemand D, Yaniv M, Rubin L L

Abstract excerpt

Sympathetic neurons depend on nerve growth factor (NGF) for survival and die by apoptosis in its absence. We have investigated the pattern of expression of the Jun and Fos family of transcription factors in dying sympathetic neurons using antibodies specific for each family member. When sympathet...

Topics

Animals
Apoptosis
Base Sequence
Cells, Cultured
Ganglia, Sympathetic
Gene Expression
Genes, jun
Molecular Sequence Data
Mutation
Nerve Growth Factors
Neurons
Proto-Oncogene Proteins c-jun
Rats
Rats, Sprague-Dawley

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