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Article

A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death.

Neuron - 1 May 1995

Ham J, Babij C, Whitfield J, Pfarr C M, Lallemand D, Yaniv M, Rubin L L

Abstract excerpt

Sympathetic neurons depend on nerve growth factor (NGF) for survival and die by apoptosis in its absence. We have investigated the pattern of expression of the Jun and Fos family of transcription factors in dying sympathetic neurons using antibodies specific for each family member. When sympathetic neurons are deprived of NGF, the level of c-Jun protein significantly increases, whereas the levels of the other...

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Source

Identifiers

PMID: 7748560
DOI: 10.1016/0896-6273(95)90331-3

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death.PMID 7748560Read ↗

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The proapoptotic dp5 gene is a direct target of the MLK-JNK-c-Jun pathway in sympathetic neurons.Semantic proximity Read ↗

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