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Article

Reduced replication capacity of NL4-3 recombinant viruses encoding reverse transcriptase-integrase sequences from HIV-1 elite controllers.

Journal of acquired immune deficiency syndromes (1999) - 1 Feb 2011

Brumme Zabrina L, Li Chun, Miura Toshiyuki, Sela Jennifer, Rosato Pamela C, Brumme Chanson J, Markle Tristan J, Martin Eric, Block Brian L, Trocha Alicja, Kadie Carl M, Allen Todd M, Pereyra Florencia, Heckerman David, Walker Bruce D, Brockman Mark A

Abstract excerpt

BACKGROUND: Identifying viral and host determinants of HIV-1 elite control may help inform novel therapeutic and/or vaccination strategies. Previously, we observed decreased replication capacity in controller-derived viruses suggesting that fitness consequences of human leukocyte antigen (HLA) cl...

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Identifiers

PMID: 21124229
DOI: 10.1097/QAI.0b013e3181fe9450
PMCID: PMC3078702

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21124229-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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