Lack of association between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals.

doi:10.1128/JVI.06533-11

Article

Lack of association between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals.

Journal of virology - 1 Jan 2012

Wright Jaclyn K, Brumme Zabrina L, Julg Boris, van der Stok Mary, Mncube Zenele, Gao Xiaojiang, Carlson Jonathan M, Goulder Philip J R, Walker Bruce D, Brockman Mark A, Ndung'u Thumbi

Abstract excerpt

It is unknown whether favorable HLA class II alleles may attenuate HIV-1 through selection pressure in a manner similar to that of protective HLA class I alleles. We investigated the relationship between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals. No associations were found between individual alleles...

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Lack of association between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals.

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