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Article

Uncommon Pathways of Immune Escape Attenuate HIV-1 Integrase Replication Capacity

12 Apr 2012

Abstract excerpt

An attenuation of the HIV-1 replication capacity (RC) has been observed for immune-mediated escape mutations in Gag restricted by protective HLA alleles. However, the extent to which escape mutations affect other viral proteins during natural infection is not well understood. We generated recombinant viruses encoding plasma HIV-1 RNA integrase sequences from antiretroviral-naïve individuals with early (n = 88)...

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PMID: 22496233
DOI: 10.1128/jvi.07133-11

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