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Article

HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1.

Journal of virology - 1 Jan 2009

Miura Toshiyuki, Brockman Mark A, Brumme Zabrina L, Brumme Chanson J, Pereyra Florencia, Trocha Alicja, Block Brian L, Schneidewind Arne, Allen Todd M, Heckerman David, Walker Bruce D

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1)-infected persons who maintain plasma viral loads of <50 copies RNA/ml without treatment have been termed elite controllers (EC). Factors contributing to durable control of HIV in EC are unknown, but an HLA-dependent mechanism is suggested by overrepresentation of "protective" class I alleles, such as B*27, B*51, and B*57. Here we investigated the relative replication...

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Share to gag Gene Products, Human Immunodeficiency Virus
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA Antigens

Share to Recombination, Genetic

Share to RNA, Viral

Share to Sequence Homology

Share to T-Lymphocytes, Cytotoxic

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Source

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Identifiers

PMID: 18971283
DOI: 10.1128/JVI.01471-08
PMCID: PMC2612337

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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