Article

Canonical and Alternative Pathways (Insulin and Exercise) of GLUT4 Synthesis, Signaling, Intracellular Clustering, and Recruitment to the Plasma Membrane

2026-03-09

Abstract excerpt

Glucose transporter type 4 (GLUT4), encoded by the SLC2A4 gene, is the final effector of insulin-stimulated glucose uptake in insulin-sensitive tissues: skeletal muscle, adipose tissue, and cardiac muscle. Its dynamic localization, retained intracellularly under basal conditions and massively translocated to the plasma membrane upon stimulation, makes it a master regulator of glycemic homeostasis. While the canoni...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d23fb8e6-8c7d-5c1c-9fa1-9ad71dd1046d
DOI: 10.20944/preprints202603.0557.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Canonical and Alternative Pathways (Insulin and Exercise) of GLUT4 Synthesis, Signaling, Intracellular Clustering, and Recruitment to the Plasma MembraneDOI 10.20944/preprints202603.0557.v1Read

Signaling and Gene Expression in Skeletal Muscles in Type 2 Diabetes: Current Results and OMICS PerspectivesSemantic proximity Read

Fatty acid transport and transporters in muscle are critically regulated by Akt2.Semantic proximity Read

A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism.Semantic proximity Read

Myo1c regulates glucose uptake in mouse skeletal muscle.Semantic proximity Read

CNIH4 regulates metabolic adaptations to exercise through β-adrenergic receptor-mediated ECM remodelingSemantic proximity Read

Insulin Signaling Attenuates GLUT4 Endocytosis in Muscle Cells <i>via</i> GSK3α-Dyn2-Bin1 InterplaySemantic proximity Read

[Insulin resistance and glucose transporter].Semantic proximity Read

Live cell GLUT4 translocation assay reveals <i>Per3</i> as a novel regulator of circadian insulin sensitivity in skeletal muscle cellsSemantic proximity Read

GLUT4 facilitates insulin stimulation and cAMP-mediated inhibition of glucose transport.Semantic proximity Read

A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis.Semantic proximity Read

Interplay of PAK1 and CAMKII in Pancreatic Beta Cell Insulin SecretionSemantic proximity Read

Glucose transporter 4 (GLUT4) distribution on metabolic healthy obese (MHO) vs metabolic unhealthy obese (MUO)Semantic proximity Read