Article
Myo1c regulates glucose uptake in mouse skeletal muscle.
The Journal of biological chemistry - 11 Feb 2011
Toyoda Taro, An Ding, Witczak Carol A, Koh Ho-Jin, Hirshman Michael F, Fujii Nobuharu, Goodyear Laurie J
Abstract excerpt
Contraction and insulin promote glucose uptake in skeletal muscle through GLUT4 translocation to cell surface membranes. Although the signaling mechanisms leading to GLUT4 translocation have been extensively studied in muscle, the cellular transport machinery is poorly understood. Myo1c is an actin-based motor protein implicated in GLUT4 translocation in adipocytes; however, the expression profile and role of...
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