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Article

Exon 6 variants carried on systemic lupus erythematosus (SLE) risk haplotypes modulate IRF5 function.

Autoimmunity - 1 Mar 2011

Wen Feng, Ellingson Sonja M, Kyogoku Chieko, Peterson Erik J, Gaffney Patrick M

Abstract excerpt

Interferon regulatory factor 5 (IRF5) regulates innate immune responses to viral infection. IRF5 genetic variants have been shown to be strongly associated with risk for systemic lupus erythematosus (SLE). Functional roles of IRF5 exon 6 structural variants that occur as part of a SLE risk-associated haplotype, including a 30-bp in/del (in/del-10) and a 48-bp splice-site variant (SV-16), have not been...

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Identifiers

PMID: 20695768
DOI: 10.3109/08916934.2010.491842
PMCID: PMC3104271

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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