Article
Impact of the HTR3A gene with early life trauma on emotional brain networks and depressed mood.
Depression and anxiety - 1 Aug 2010
Gatt Justine M, Williams Leanne M, Schofield Peter R, Dobson-Stone Carol, Paul Robert H, Grieve Stuart M, Clark C Richard, Gordon Evian, Nemeroff Charles B
Abstract excerpt
BACKGROUND: The risk for mental illnesses such as depression is increasingly conceptualized as the product of gene-environment interactions and their impact on brain structure and function. The role of serotonin 3A receptor gene (HTR3A -42C>T polymorphism) and its interaction with early life stress (ELS) was investigated in view of the receptor's localization to brain regions central to emotion processing....
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