Article
Early adversity and 5-HTT/BDNF genes: new evidence of gene-environment interactions on depressive symptoms in a general population.
Psychological medicine - 1 Sept 2009
Aguilera M, Arias B, Wichers M, Barrantes-Vidal N, Moya J, Villa H, van Os J, Ibáñez M I, Ruipérez M A, Ortet G, Fañanás L
Abstract excerpt
BACKGROUND: Adverse childhood experiences have been described as one of the major environmental risk factors for depressive disorder. Similarly, the deleterious impact of early traumatic experiences on depression seems to be moderated by individual genetic variability. Serotonin transporter (5-HTT) and brain-derived neurotrophic factor (BDNF) modulate the effect of childhood adversity on adult depression,...
Topics
- Adolescent
- Adult
- Alleles
- Brain-Derived Neurotrophic Factor
- Child
- Child Abuse
- Depressive Disorder
- Epistasis, Genetic
- Female
- Gene Expression Regulation
- Genetic Predisposition to Disease
- Genotype
- Humans