Article
Serotonin transporter gene methylation is associated with hippocampal gray matter volume.
Human brain mapping - 1 Nov 2014
Dannlowski Udo, Kugel Harald, Redlich Ronny, Halik Adriane, Schneider Ilona, Opel Nils, Grotegerd Dominik, Schwarte Kathrin, Schettler Christiane, Ambrée Oliver, Rust Stephan, Domschke Katharina, Arolt Volker, Heindel Walter, Baune Bernhard T, Suslow Thomas, Zhang Weiqi, Hohoff Christa
Abstract excerpt
BACKGROUND: The serotonin transporter (5-HTT) and the 5-HTTLPR/rs25531 polymorphisms in its gene (SLC6A4) have been associated with depression, increased stress-response, and brain structural alterations such as reduced hippocampal volumes. Recently, epigenetic processes including SLC6A4 promoter...
Topics
- Adult
- Brain Mapping
- DNA Methylation
- Female
- Genotype
- Gray Matter
- Hippocampus
- Humans
- Image Processing, Computer-Assisted
- Magnetic Resonance Imaging
- Male