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Article

CYP46A1 functional promoter haplotypes decipher genetic susceptibility to Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2010

Li Yan, Chu Leung-Wing, Wang Binbin, Yik Ping-Yiu, Huriletemuer, Jin Dong-Yan, Ma Xu, Song You-Qiang

Abstract excerpt

We here demonstrate that promoter polymorphisms rs8003602 and rs3783320 of cholesterol 24S-hydroxylase (CYP46A1) were significantly associated with Alzheimer's disease (AD) in Chinese subjects. Haplotype analyses showed that haplotype CG is the risk haplotype. Either single marker or haplotypic association was found only in the APOE ε4 negative group. The association was then replicated in an independent set of...

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Source

Identifiers

PMID: 20693622
DOI: 10.3233/JAD-2010-100765

Genes

APOE
MYT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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