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Article

Functional Study of Haplotypes in UGT1A1 Promoter to Find a Novel Genetic Variant Leading to Reduced Gene Expression.

Therapeutic drug monitoring - 1 Jun 2015

Shin Hee Jung, Kim Jason Yongha, Cheong Hyun Sub, Na Han Sung, Shin Hyoung Doo, Chung Myeon Woo

Abstract excerpt

BACKGROUND: Uridine diphosphate glucuronyltransferase 1 family, A1 (UGT1A1) encodes for an enzyme that is a part of glucuronidation pathway, and a number of studies have shown that the promoter polymorphisms of UGT1A1 are associated with various diseases and drug response. In this study, we examined a possible association between UGT1A1 promoter haplotypes and the gene expression level. METHODS: To identify...

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PMID: 25478904
DOI: 10.1097/FTD.0000000000000154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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