Article
Association of CYP46 gene polymorphism with sporadic Alzheimer's disease in Chinese Han populations: a meta-analysis.
The International journal of neuroscience - 1 Apr 2013
Jin Chunhui, Zhang Feng, Zhu Jianzhong, Yuan Jianmin, Xia Minghua, Xu Qing, Jiang Xingyan, Wu Yue, Xu Wenwei
Abstract excerpt
It is well known that genetic variants play an important role in the pathogenesis of Alzheimer's disease (AD). Recently, several studies have found that an intronic single-nucleotide polymorphism (SNP) in cholesterol 24S-hydroxylase (CYP46) gene was associated with sporadic AD (SAD). Within the CYP46 gene, the most well-studied SNP that has been found to be associated with an increased risk for SAD in Caucasians...
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