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Article

CYP46A1 T/C polymorphism associated with the APOE ε4 allele increases the risk of Alzheimer's disease.

Journal of neurology - 1 Jul 2013

Li Ling, Yin Zegang, Liu Juan, Li Gongbo, Wang Yanjiang, Yan Jiachuan, Zhou Huadong

Abstract excerpt

Studies of the relationship between Alzheimer's disease (AD) and single nucleotide polymorphism (SNP) T/C in intron 2 of the cholesterol-24S-hydroxylase gene (CYP46A1) have reported inconsistent results. To confirm the association between the CYP46A1 T/C polymorphism and AD risk, a meta-analysis containing 4,875 AD cases and 4,874 controls from 21 case-control studies was performed. There were 16 studies...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23070465
DOI: 10.1007/s00415-012-6690-4

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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