Article
Polymorphisms of the cholesterol 24-hydroxylase (CYP46A1) gene and the risk of Alzheimer's disease in a Chinese population.
International psychogeriatrics - 1 Mar 2006
Ma Suk Ling, Tang Nelson Leung Sang, Lam Linda Chiu Wa, Chiu Helen Fung Kum
Abstract excerpt
BACKGROUND: An increasing number of studies have suggested a link between cholesterol metabolism and Alzheimer's disease (AD), which may be mediated by its effect on amyloid processing. Intracranial cholesterol is primarily eliminated into the bloodstream through conversion into 24-hydroxycholesterol by the enzyme cholesterol 24-hydroxylase (encoded by the CYP46A1 gene). CYP46A1 is an essential gene modulating...
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