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Article

Insulin transactivator MafA regulates intrathymic expression of insulin and affects susceptibility to type 1 diabetes.

Diabetes - 1 Oct 2010

Noso Shinsuke, Kataoka Kohsuke, Kawabata Yumiko, Babaya Naru, Hiromine Yoshihisa, Yamaji Kaori, Fujisawa Tomomi, Aramata Shinsaku, Kudo Takashi, Takahashi Satoru, Ikegami Hiroshi

Abstract excerpt

OBJECTIVE: Tissue-specific self-antigens are ectopically expressed within the thymus and play an important role in the induction of central tolerance. Insulin is expressed in both pancreatic islets and the thymus and is considered to be the primary antigen for type 1 diabetes. Here, we report the role of the insulin transactivator MafA in the expression of insulin in the thymus and susceptibility to type 1...

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Source

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Identifiers

PMID: 20682694
DOI: 10.2337/db10-0476
PMCID: PMC3279543

Genes

MAFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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