Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional Domains of Autoimmune Regulator (AIRE) Modulate INS-VNTR Transcription in Human Thymic Epithelial Cells.

The Journal of biological chemistry - 20 May 2016

Sparks Avis E, Chen Chiachen, Breslin Mary B, Lan Michael S

Abstract excerpt

INS-VNTR (insulin-variable number of tandem repeats) and AIRE (autoimmune regulator) have been associated with the modulation of insulin gene expression in thymus, which is essential to induce either insulin tolerance or the development of insulin autoimmunity and type 1 diabetes. We sought to analyze whether each functional domain of AIRE is critical for the activation of INS-VNTR in human thymic epithelial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AIRE Protein
Share to Cell Line
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial Cells

Share to Protein Structure, Tertiary

Share to Thymus Gland

Share to Transcription Factors

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 27048654
DOI: 10.1074/jbc.M116.722488
PMCID: PMC4900276

Genes

AIRE
INS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional Domains of Autoimmune Regulator (AIRE) Modulate INS-VNTR Transcription in Human Thymic Epithelial Cells.PMID 27048654Read ↗

AIRE-mutations and autoimmune disease.Semantic proximity Read ↗

Aire in Autoimmunity.Semantic proximity Read ↗

A novel mutation in autoimmune regulator gene causes autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.Semantic proximity Read ↗

High-Resolution Transcriptional Impact of AIRE: Effects of Pathogenic Variants p.Arg257Ter, p.Cys311Tyr, and Polygenic Risk Variant p.Arg471CysSemantic proximity Read ↗

AIRE expands: new roles in immune tolerance and beyond.Semantic proximity Read ↗

Autoimmune polyglandular syndrome type 1 and the autoimmune regulator.Semantic proximity Read ↗

APECED mutations in the autoimmune regulator (AIRE) gene.Semantic proximity Read ↗

Gene Dosage–limiting Role of <i>Aire</i> in Thymic Expression, Clonal Deletion, and Organ-specific AutoimmunitySemantic proximity Read ↗

Dominant Mutations in the Autoimmune Regulator AIRE Are Associated with Common Organ-Specific Autoimmune Diseases.Semantic proximity Read ↗

Update on Aire and thymic negative selection.Semantic proximity Read ↗

The AIRE -230Y Polymorphism Affects AIRE Transcriptional Activity: Potential Influence on AIRE Function in the Thymus.Semantic proximity Read ↗

Insulin transactivator MafA regulates intrathymic expression of insulin and affects susceptibility to type 1 diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.