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Article

Insulin alleles and autoimmune regulator (AIRE) gene expression both influence insulin expression in the thymus.

Journal of autoimmunity - 1 Dec 2005

Sabater Lidia, Ferrer-Francesch Xavier, Sospedra Mireia, Caro Pepi, Juan Manel, Pujol-Borrell Ricardo

Abstract excerpt

It is well established that the polymorphisms at the 5' of the insulin gene (IDDM2) confers susceptibility to type 1 diabetes, probably by modifying the level of insulin expression in the thymus that in turn influences immunological tolerance to insulin as self-antigen. AIRE is a transcription regulator which controls the expression of many peripheral antigens within the thymus, among them insulin. Results...

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Identifiers

PMID: 16246524
DOI: 10.1016/j.jaut.2005.08.006

Genes

AIRE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Insulin alleles and autoimmune regulator (AIRE) gene expression both influence insulin expression in the thymus.PMID 16246524Read ↗

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Class III alleles of the variable number of tandem repeat insulin polymorphism associated with silencing of thymic insulin predispose to type 1 diabetes.Semantic proximity Read ↗

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