Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs.

The Journal of clinical investigation - 1 Mar 2001

Pugliese A, Brown D, Garza D, Murchison D, Zeller M, Redondo M J, Redondo M, Diez J, Eisenbarth G S, Patel D D, Ricordi C

Abstract excerpt

Recent reports indicate that genes with tissue-restricted expression, including those encoding the type 1 diabetes autoantigens insulin, glutamic acid decarboxylase (GAD), and the tyrosine-phosphatase-like protein IA-2 (or ICA512), are transcribed in the thymus. The reported modulation of diabetes susceptibility by genetically determined differences in thymic insulin levels and studies in transgenic mice provide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigen-Presenting Cells
Share to Autoantigens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glutamate Decarboxylase

Share to Lymph Nodes

Share to Proinsulin

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 1

Share to Self Tolerance

Share to Thymus Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 11238556
DOI: 10.1172/JCI10860
PMCID: PMC199421

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs.PMID 11238556Read ↗

Differential Splicing of the IA-2 mRNA in Pancreas and Lymphoid Organs as a Permissive Genetic Mechanism for Autoimmunity Against the IA-2 Type 1 Diabetes AutoantigenSemantic proximity Read ↗

Insulin transactivator MafA regulates intrathymic expression of insulin and affects susceptibility to type 1 diabetes.Semantic proximity Read ↗

The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.Semantic proximity Read ↗

Alternative splicing and differential expression of the islet autoantigen IGRP between pancreas and thymus contributes to immunogenicity of pancreatic islets but not diabetogenicity in humans.Semantic proximity Read ↗

Identification of the β cell antigen targeted by a prevalent population of pathogenic CD8 <sup>+</sup> T cells in autoimmune diabetesSemantic proximity Read ↗

Thymic B Cells as a New Player in the Type 1 Diabetes Response.Semantic proximity Read ↗

Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetesSemantic proximity Read ↗

Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunitySemantic proximity Read ↗

Pancreatic islet cell phenotype and endocrine function throughout diabetes development in non-obese diabetic mice.Semantic proximity Read ↗

Islet autoimmunity in phenotypic type 2 diabetes patients.Semantic proximity Read ↗

Islet-Resident Dendritic Cells and Macrophages in Type 1 Diabetes: In Search of Bigfoot’s PrintSemantic proximity Read ↗

Islet abnormalities in the pathogenesis of autoimmune diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.