Article
Mannose-binding lectin (MBL2) and ficolin-2 (FCN2) polymorphisms in patients on peritoneal dialysis with staphylococcal peritonitis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Mar 2011
Meijvis Sabine C A, Herpers Bjorn L, Endeman Henrik, de Jong Ben, van Hannen Erik, van Velzen-Blad Heleen, Krediet Raymond T, Struijk Dirk G, Biesma Douwe H, Bos Willem Jan W
Abstract excerpt
BACKGROUND: Mannose-binding lectin (MBL) and ficolin-2 (FCN) are activators of the lectin pathway of complement and act as primary defences against infection. Single-nucleotide polymorphisms (SNPs) in the MBL2 and FCN2 genes influence the functionality of the proteins. Both proteins are capable of binding staphylococci, which are pathogens that frequently cause peritonitis in patients on continuous ambulatory...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.